Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

By Keisuke Ito, A. Hirao, F. Arai, S. Matsuoka, K. Takubo, I. Hamaguchi, K. Nomiyama, Kentaro Hosokawa, K. Sakurada, N. Nakagata and 3 more. Nature, 2004

1,221 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/00cd17677ead05ec3a33188f5214980b7161b539

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Citations in the corpus

Mechanism and regulation of class switch recombination. (2008, background): “If B cells were to downregulate BER during CSR, this could be dangerous, given the great amount of reactive oxygen species produced during B cell activation and proliferation (86).”
The stem-cell niche as an entity of action (2006, background): “Under conditions in which ‘ataxia telangiectasia mutated’ (ATM) deficiency was induced, reactive oxygen species (ROS) accumulated in HS cells in the bone marro”
The regulation of INK4/ARF in cancer and aging. (2006, neutral): “Oxidative stress has also been suggested to induce an Ink4a/Arf-depend- ent decline in HSC function (Ito et al., 2004, 2006).”
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (2009, background): “Recent studies showed that normal haemopoietic stem cells and normal mammary epithelial stem cells maintained ROS at lower levels than their mature progeny to prevent cellular differentiation and maintain long-term self-renewa”
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “…cycle/quiescence, apoptosis, and intracellular redox status in the maintenance and fate determination within tissue stem cell compartment (Cheng et al., 2000a, 2000b; Doetsch et al., 2002b; Ito et al., 2004, 2006; Kippin et al., 2005; Kozar et al., 2004; Malumbres et al., 2004; Yuan et al., 2004).”
ROS Function in Redox Signaling and Oxidative Stress (2014, background): “Indeed, ROS oxidize a specific cysteine residue on ATM to generate disulfide-linked activated ATM dimers that promote antioxidant responses Stem cell renewal Proliferation and differentiation Healthy immune responses Longevity Stem cell exhaustion Tumorigenesis Autoimmunity Senescence ROS Current Bi”
Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Atm / mice also show a defect in HSC self-renewal and exhibit a progressive decline in HSCs with age (Ito et al., 2004).”
ATM Activation by Oxidative Stress (2010, background): “Treatment with anti-oxidative agents restored the reconstitutive capacity of HSC and prevented bone marrow failure [62].”
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. (2007, methodology): “After 6 weeks of culture, we quantified LTC-IC frequency.(24) For some experiments, 100uM N-acetyl-L-cysteine (NAC, Sigma, Chemical Co.”
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “, their relative resistance to oxidative or DNA damage, and their efficiency of DNA repai”
Mitochondria: In Sickness and in Health (2012, background): “Observations from premature aging mouse models suggest that hematopoietic progenitors are especially sensitive to ROS and/or redox state changes that promote proliferation and prevent quiescence (Ito et al., 2004; Narasimhaiah et al., 2005).”
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (2006, methodology): “, for 2 d increased levels of hydroxyperoxide (H 2 O 2 ), which were measured by staining with 2′-7′-dichlorofluorescene diacetate (DCF-DA”