The stem-cell niche as an entity of action

By D. Scadden. Nature, 2006

1,944 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0a39036a4f603e1929f42e8c526a27db0da87cd9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Fred H. Gage
2. G. T. Huang
3. S. Shi
4. Helen M. Blau
5. S. Gronthos
6. W. Sonoyama
7. M. Lutolf
8. J. Ray

In Molecular Biology

1. Fred H. Gage
2. S. Shi
3. Helen M. Blau
4. G. T. Huang
5. S. Gronthos
6. Jeremy N. Rich
7. Irving L. Weissman
8. J. Ray

In Oncology

1. A. Pocheville
2. S. Shi
3. S. Gronthos
4. P. Bonaldo
5. Jeremy N. Rich
6. Melinda Larsen
7. William P. Daley
8. Hu Zhang

Citations in the corpus

• Tumors as organs: complex tissues that interface with the entire organism (2010, neutral): “Supporting cells (e.g., cap cells in the Drosophila ovary and endothelial cells in the brain), ECM, and signaling molecules constitute classical stem cell niches (Sato et al., 2009; Scadden, 2006).”
• Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “These two niches are proposed to be associated with the dormant and activated HSCs, respectively [118–120].”
• Cancer heterogeneity—a multifaceted view (2013, neutral): “Part of these signals emanate from the microenvironment, commonly referred to as the ‘stem cell niche’ [57].”
• Designing materials to direct stem-cell fate (2009, background): “In the body, adult stem cells reside within instructive, tissue-specific niches that physically localize them and maintain their stem-cell fat”
• Optical tweezers for single cells (2008, background): “These elements have to be placed to their anatomic and functional locations and the contact between these elements allows molecular interactions that are crucial for regulating stem cell function (Scadden 2006).”
• In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, background): “The homeostatic balance between maintenance of NSCs and their cell fate choice upon differentiation is determined by the interactions between NSCs and the microenvironment referred as to a niche (reviewed in Palmer, 2002; Scadden, 2006).”
• IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro (2007, background): “i, Western blot of SMAD2/3 in control (–) and TGF-b inhibited (1) human ES cell cultures compared to hdFs; baseline.”
• The Ecological Niche: History and Recent Controversies (2015, background): “Because of its impact on the tissue that surrounds it, the stem cell niche is considered a promising therapeutic target (Li and Xie 2005 : 623; Scadden 2006 : 1078).”
• Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche (2009, background): “Stem cells are generally influenced by a microenvironmental niche, typically comprised of epithelial and mesenchymal cells and extracellular substrates, which instructs either self-renewal or selective adoption of a particular cell lineag”
• Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “They are regulated by growth factors and other signals from a local microenvironment called the niche (Scadden, 2006).”
• Making a tumour's bed: glioblastoma stem cells and the vascular niche (2007, background): “Stem cell niches are not merely repositories for stem cells, but are complex dynamic entities that actively regulate stem cell functio”
• Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “David Scadden determines a niche of stem cells as «a specific anatomical formation that regulates behavior of stem cells that participate in tissue regeneration and supports its functioning» [51].”