Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

By Bin-Bing S. Zhou, Haiying Zhang, M. Damelin, K. Geles, J. Grindley, P. Dirks. Nature reviews. Drug discovery, 2009

867 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3ffe91ef45c94689ede866e3415aeb89c38863f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Anurag Singh
2. Hans Clevers
3. J. Settleman

In Molecular Biology

1. Jeremy N. Rich
2. Anurag Singh
3. T. Schatton
4. Hans Clevers
5. M. Frank
6. N. Frank
7. J. Settleman
8. R. Nusse

In Oncology

1. Jeremy N. Rich
2. J. Lathia
3. Anurag Singh
4. T. Schatton
5. Hans Clevers
6. M. Frank
7. N. Frank
8. J. Settleman

Citations in the corpus

• Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells (2013, background): “…of highly tumorigenic, stem-like cells (GSCs) (Dirks, 2010; Hemmati et al., 2003; Singh et al., 2004), and that GSCs are responsible for glioma propagation, resistance to conventional therapy, and tumor recurrence (Bao et al., 2006; Chen et al., 2012; Gilbert and Ross, 2009; Zhou et al., 2009).”
• EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer (2010, background): “Furthermore, cells with different molecular characteristics within the same tumor respond differently to anticancer therapeutics, leading to drug resistance (Zhou et al., 2009).”
• The cancer stem cell: premises, promises and challenges (2011, background): “Are CSCs therapy resistant? It is often suggested that CSCs are resistant to therapy in the same way that normal stem cells are protected against insult; these protections include, for example, mechanisms such as quiescence, expression of ABC drug pumps, high expression of antiapoptotic proteins an”
• Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth (2013, positive): “GBMs display remarkable cellular hierarchies with tumorigenic glioma stem cells (GSCs) at the apex (Bao et al., 2006a; Calabrese et al., 2007; Zhou et al., 2009), although the cancer A B C D”
• The therapeutic promise of the cancer stem cell concept. (2010, background): “30, 32), are already being translated to the clinic (125).”