ATM Activation by Oxidative Stress

By Zhi Guo, S. Kozlov, M. Lavin, M. Person, T. Paull. Science, 2010

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DNA damage sensing by the ATM and ATR kinases. (2013, background): “It is interesting to note that ionizing radiation (IR) not only induces DSBs but also reactive oxygen species (ROS), which may directly trigger ATM autophosphorylation and promote its localization to DSBs (Guo et al. 2010).”
ROS Function in Redox Signaling and Oxidative Stress (2014, background): “by regulating NADPH production from the pentose phosphate pathway [133,134].”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “For example, hydrogen peroxide activates many signalling pathways, including the kinase ATM (Guo et al. 2010), and”
Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection (2014, background): “ATM is also directly activated by IR-induced ROS, facilitating dimerization through the formation of an intermolecular disulfide (93, 137).”
Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Moreover, ATM is reportedly a critical sensor of oxidative stress (Guo et al., 2010).”
Causes and consequences of aneuploidy in cancer (2012, background): “A potential signalling mechanism is through ROS-mediated activation of the DNA damage response protein ataxia telangiectasia mutated (ATM”