The enzymes and control of eukaryotic mRNA turnover

By R. Parker, Haiwei Song. Nature Structural &Molecular Biology, 2004

887 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0018e34229d6e9c482c8510e32051b3f118f83dc

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Citations in the corpus

P bodies: at the crossroads of post-transcriptional pathways (2007, background): “P bodies are sites of mRNA decay In eukaryotic cells, degradation of bulk mRNA occurs by two alternative pathways, both of which are preceded by removal of the poly(A) tail by deadenylases ( Box 1 ; reviewed in Ref”
XRN 5’→3’ exoribonucleases: Structure, mechanisms and functions (2013, background): “decapping) and subsequent degradation [2,8].”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “1A) (reviewed in Parker and Song 2004; Garneau et al. 2007) by the major mRNA deadenylase, the Ccr4/Pop2/Not complex (Daugeron et al. 2001; Tucker et al. 2001; Thore et al. 2003).”
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail (2008, background): “This oligo(U) tail is an optimal binding site for the LSM1–7 heptamer and leads to the degradation of the histone mRNA by pathways that are similar to those involved in the degradation of poly(A) mRNA after deadenylatio”
P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing (2007, background): “Drosophila Staufen, Tral, DCP1, DCP2, XRN1, and Me31B have also been detected in RNP granules in neuronal cells and/or in oocytes (5, 61), indicating that P bodies and other RNP granules observed in neuronal cells or during development share common components (3, 17).”
Processing bodies require RNA for assembly and contain nontranslating mRNAs. (2005, background): “Experiments in mammalian cells, and the conservation of the mRNA decay enzymes and factors, suggest that the major pathways are shared between yeast and mammals (for review, see Parker and Song 2004).”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “In addition, 5′–3′ exoribonuclease 1 (XRN1), a cellular exoribonuclease that is essential for efficient decay of uncapped mRN”
RNA-quality control by the exosome (2006, background): “However, due to space limitations, these pathways will not be discussed in this review and the reader is referred to Ref”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “Further evidence linking the decapping activity in the cell to the size and number of PBs strengthened such a conclusion (Parker and Song 2004).”
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “Cellular RNAs are generally subject to quality control or surveillance pathways that guard against defects in gene expression (for recent reviews, see Dimaano and Ullman 2004; Parker and Song 2004; Vinciguerra and Stutz 2004; Conti and Izaurralde 2005; Fasken and Corbett 2005; Maquat 2005; Moore 200”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Cleavage products are degraded by one of two processes responsible for bulk cellular mRNA degradation, both beginning with the deadenylation of the mRNA to remove the poly (A) tail [174, 181].”
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. (2005, background): “#-3# exonucleases typically reognize exposed 5# monophosphate-containing RNAs hat can result from mRNA decapping or endonucleoytic cleavage (Parker and Song, 2004).”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “The mRNA body can then be degraded by progressive 3′→5′ decay, which is catalysed by the exosome, or by the removal of the cap followed by 5′→3′ degradation, which is catalysed by the exonuclease XRN1 (Ref”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “Eukaryotic cells contain two general and conserved pathways for the degradation of bulk mRNA, both of which require an initial removal of the 3 poly(A) tail in a process referred to as deadenylation (Parker and Song 2004).”