MicroRNA function: multiple mechanisms for a tiny RNA?

By R. Pillai. RNA: A publication of the RNA Society, 2005

748 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/47b1dcf0a3147dd1173ec28f63e32b2da15deee1

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Citations in the corpus

miR-21-mediated tumor growth (2007, background): “MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that control gene expression by targeting mRNAs for translational repression or cleavage (Pillai, 2005; Zamore and Haley, 2005).”
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype (2007, background): “Within the silencing complex, miRNAs pair to the messages of protein-coding genes, usually through imperfect base-pairing with the 3'-untranslated region (3'UTR), thereby specifying the post-transcriptional repression of these target mRNAs [6,26].”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Evidence clearly indicates that P-bodies are essential for miRNA function as inhibition of P-body formation by depletion of GW182 (the major protein component of P-bodies) significantly impairs miRNA function [190, 203, 207].”
Processing of intronic microRNAs (2007, background): “RISC binds to the 30 untranslated region (UTR) of the target mRNA in a sequencespecific manner, and induces mRNA cleavage, translational inhibition or cleavage-independent mRNA degradation (Pillai, 2005; Valencia-Sanchez et al, 2006).”
Tumor angiogenesis: molecular pathways and therapeutic targets (2011, background): “Recent studies have shown the regulation of vascular development and angiogenesis by microRNAs (miRNAs), which are small noncoding RNAs that bind to the 3′ untranslated region of mRNAs, recruit a silencing complex and block translatio”
Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process (2008, background): “We have analyzed the role of miRNA expression in the molecular determination of cellular senescence. miRNAs constitute a group of endogenous small, non coding RNAs of approximately 22 nucleotides in length that exert a post-transcriptional effect on gene expression”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “Furthermore, it appears that each miRNA can regulate multiple mRNAs and that each mRNA can be targeted by a number of miRNAs [11].”
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways (2008, neutral): “Some miRNAs have been shown to effect cleavage of their mRNA targets [52] and changes in mRNA expression have been used to elucidate pathways regulated by miRNAs [18, 42].”