Processing bodies require RNA for assembly and contain nontranslating mRNAs.

By Daniela Teixeira, Ujwal Sheth, M. A. Valencia-Sanchez, M. Brengues, R. Parker. RNA: A publication of the RNA Society, 2005

755 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b54123ec63d4a5c106d48087f080efbffb6220f6

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Citations in the corpus

P bodies: at the crossroads of post-transcriptional pathways (2007, background): “cerevisiae , the visualization of P bodies is often enhanced by overexpressing or depleting some of the P-body components or by exposing yeast cells to stresses such as glucose deprivation or hypotonic shoc”
A role for the P-body component GW182 in microRNA function (2005, background): “These are cytoplasmic foci that contain non-translated mRNAs and exclude the translation machiner”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “P-bodies are thought to contain pools of mRNAs not engaged in translation, because P-bodies show a reciprocal relationship with polysomes, do not contain the translation machinery, and contain and require mRNAs for assembly (Andrei et al. 2005; Brengues et al. 2005; Kedersha et al. 2005; Teixeira et”
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization (2015, positive): “Multivalent RNA/RRM Domains Mediate Assembly of Large Complexes Stress granules are, of course, composed not only of RBPs but also untranslated mRNAs (Buchan and Parker, 2009; Teixeira et al., 2005), posing the question of what role RNA plays in mediating LLPS of RBPs.”
Formation and Maturation of Phase Separated Liquid Droplets by RNA Binding Proteins (2015, background): “In cells, RNP granule assembly is dependent on the concentration of specific RNAs (Teixeira et al., 2005; Buchan and Parker, 2009).”
Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies (2005, background): “It has recently been demonstrated in yeast that formation of processing bodies is dependent on the presence of RN”
P bodies and the control of mRNA translation and degradation. (2007, background): “Conversely, overexpression of Dhh1p or Pat1p in yeast leads to an inhibition of translation and an increase in P bodies (Coller and Parker, 2005).”
Mammalian stress granules and processing bodies. (2007, background): “Many fundamental studies of PBs have been performed in yeast (Sheth and Parker, 2003; Teixeira et al., 2005).”
LNCcation: lncRNA localization and function (2021, methodology): “…weaker binding of the critical splice factor U2AF65, their smaller polypyrimidine tracts, the greater distance of the branch point to the 39 splice site, or their overall lack of conserved splice sites (Melé et al., 2017; Schlackow et al., 2017; Tilgner et al., 2012; Zuckerman and Ulitsky, 2019).”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “First, inhibition of translation initiation by drugs, stresses, or mutations leads to loss of mRNAs from polysomes and a corresponding increase of mRNAs in P-bodies and stress granules (Kedersha et al. 2005; Teixeira et al. 2005; Anderson and Kedersha 2006).”