Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.
By O. Isken, L. Maquat. Genes & Development, 2007
631 citations recorded by the source corpus.
Cells routinely make mistakes. Some mistakes are encoded by the genome and may manifest as inherited or acquired diseases. Other mistakes occur because metabolic processes can be intrinsically inefficient or inaccurate. Consequently, cells have developed mechanisms to minimize the damage that would result if mistakes went unchecked. Here, we provide an overview of three quality control mechanisms--nonsense-mediated mRNA decay, nonstop mRNA decay, and no-go mRNA decay. Each surveys mRNAs during translation and degrades those mRNAs that direct aberrant protein synthesis. Along with other types of quality control that occur during the complex processes of mRNA biogenesis, these mRNA surveillance mechanisms help to ensure the integrity of protein-encoding gene expression.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b3e3898f83ba4f52174e3162c8b04565914ee182
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In Molecular Biology
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Citations in the corpus
- Pre-mRNA processing reaches back to transcription and ahead to translation. (2009, neutral): “…mutant alleles containing a frameshift or nonsense codon produced for example by unproductive rearrangements at V(D)J loci in B and T cells or from errors introduced into individual mRNA molecules by the transcription and premRNA processing machineries (Chang et al., 2007; Isken and Maquat, 2007).”
- XRN 5’→3’ exoribonucleases: Structure, mechanisms and functions (2013, background): “As part of the cytoplasmic mRNA surveillance system, aberrant mRNAs, mainly NMD substrates, also predominantly undergo 5′ → 3′ degradation without the need for deadenylation [44,46].”
- Complexity of the Alternative Splicing Landscape in Plants[C][W][OPEN] (2013, methodology): “In Arabidopsis, SR and SR-like proteins RS41, CypRS64, and SR45a were found to have phosphorylation sites specific for single splice variants (de la Fuente van Bentem et al., 2006).”