RNA-quality control by the exosome

By J. Houseley, J. LaCava, David Tollervey. Nature reviews. Molecular cell biology, 2006

663 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e7fc0c8cc31714daf968ef7a8a1b143cd94f38a7

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In Molecular Biology

Citations in the corpus

P bodies: at the crossroads of post-transcriptional pathways (2007, background): “Following this first rate-limiting step, mRNAs can undergo 3′→5′ exonucleolytic decay, which is catalysed by the exosome , and the exosome activity is regulated by the SKI comple”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, neutral): “In eukaryotes, a barrel-shaped multi-protein complex, called exosome, [1440, 1441, 1442, 1443, 1444, 1445] degrades RNA molecules.”
XRN 5’→3’ exoribonucleases: Structure, mechanisms and functions (2013, background): “Unspliced and incorrectly polyadenylated RNAP II transcripts undergo degradation by the nuclear exosome [17,49].”
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “…across the nuclear pore complex, are also subject to quality control (Dimaano and Ullman 2004; Vinciguerra and Stutz 2004; Fasken and Corbett 2005; Saguez et al. 2005; Houseley et al. 2006), protein-encoding RNAs are likely to be scrutinized at every stage of their biogenesis and function.”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “ARE-binding proteins function by targeting AU-rich RNA to the exosome for degradation or by recruitment of alternative degradation factors (87, 139).”
A census of human RNA-binding proteins (2014, background): “(i) Incorrectly processed RNAs are recognized by a number of complexes in the nucleus and cytoplasm that initiate and execute their degradation (Doma and Parker, 2007; Houseley et al., 2006).”
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs (2007, background): “Aberrant RNAs or RNPs seem to be targeted for destruction by a mechanism that involves nuclear polyadenylation by the TRAMP complex and degradation by the exosome”
P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing (2007, background): “Following deadenylation, mRNAs are exonucleolytically digested from their 3 end by the exosome, a multimeric complex with 3 -to-5 exonuclease activity (24).”
The many pathways of RNA degradation. (2009, background): “Leading Edge”
Exporting RNA from the nucleus to the cytoplasm (2007, background): “Apart from pre-mRNA turnover, the exosome is also responsible for degrading aberrant tRNAs, snRNAs, small nucleolar RNAs and rRNA”