Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis

By M. Greter, Frank Heppner, Maria P. Lemos, Bernhard Odermatt, N. Goebels, T. Laufer, R. Noelle, B. Becher. Nature Medicine, 2005

891 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/fb82cebf720ce1b848d3b7a740e52350ac1c2fd4

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In Immunology

1. R. Ransohoff
2. Marco Prinz
3. Josef Priller
4. V. Perry
5. I. Galea
6. J. Goverman
7. U. Hanisch
8. M. Mack

Citations in the corpus

• Autoimmune T cell responses in the central nervous system (2009, background): “Despite the low abundance of DCs in these compartments, experiments that limited MHC class II expression to DCs showed that these cells are sufficient to support the development of EA”
• Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation (2019, background): “Additionally, the antigen presentation required for T cell activation (18) has been attributed to either major histocompatibility complex (MHC) class II CNS intrinsic cells (19) or circulating DCs (20).”
• The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. (2006, background): “We can not exclude the possibility that the rare DCs identified within the gliomas could act as APCs mediating immune responses within the immunosuppressive environment, especially since recent studies in murine experimental allergic encephalomyelitis models have described a minority population of C”
• High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (2018, neutral): “Several studies assign this role either to DCs or BAMs during the initiation of EAE (Greter et al., 2005; Kivis€ akk et al., 2009; Schl€ ager et al., 2016).”
• Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. (2006, background): “Although it has been formally shown that AT-EAE can be induced in splenectomized Aly mice lacking secondary lymphoid organs (Greter et al., 2005), these mice still have residual, unstructured lymphoid tissue that may exert the same role of re-programming injected T cells as in naı¨ve mice.”
• Inflammatory mechanisms in ischemic stroke: role of inflammatory cells (2010, background): “In multiple sclerosis, mDCs invade the human brain, subsequently triggering cerebral inflammation [108].”
• CNS immune privilege: hiding in plain sight (2006, background): “(97) demonstrated that adoptive transfer EAE could be supported in the absence of secondary lymphoid tissue.”
• The blood–brain barrier in health and disease: Important unanswered questions (2020, background): “Several regions of the CNS termed circumventricular organs (CVOs)—the area postrema, subfornical organ, pineal gland, and median eminence of the hypothalamus— have fenestrated capillaries that lack BBB properties (Box 1; Gross, 1992).”
• Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions (2007, methodology): “Bone-marrow chimeric mice were generated as described recentl”
• The blood–brain barrier in systemic infection and inflammation (2021, background): “They require an activation step in the perivascular space before they can proceed to cross the glial layer; [48] this passage is enabled by selective cleavage of dystroglycan, a transmembrane receptor that anchors astrocyte endfeet to the glial basement membrane by focal MMP-2 and MMP-9 action [54].”
• RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation (2011, background): “It has been reported that microglia are not pertinent antigen-presenting cell”
• Microglial physiology: unique stimuli, specialized responses. (2009, background): “In follow-up studies, eliminating all potential APCs except for CD11c+ PVMs produced mice that remained susceptible to adoptive-transfer EAE (40).”
• Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “Perivascular cells in the CNS are CD11C + dendritic cells that present antigen to primed myelin-reactive T cells and are thought to initiate experimental autoimmune encephalomyelitis (EAE”