Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

By R. Jin, Guojun Yang, Guohong Li. Journal of Leukocyte Biology, 2010

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The biphasic function of microglia in ischemic stroke (2017, neutral): “Microglia activation is the first step of inflammatory response in the brain, followed by infiltration of immune cells such as neutrophils, macrophages/monocytes, natural killer cells, T cells, and other neuronal cell activation (Iadecola and Anrather, 2011; Jin et al., 2010).”
Post-stroke dementia – a comprehensive review (2017, background): “Activation of resident cells (microglia, astrocytes, and endothelial cells) appears to be neuroprotective and promotes brain regeneration/recovery, whereas recruitment of immune cells with a subsequent increase in the expression of inflammatory mediators, such as reactive oxygen species, cytokines, ”
Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases (2014, background): “Inflammation accompanying stroke plays an important role in secondary ischemic injury [57].”
Vascular Contributions to Cognitive Impairment and Dementia Including Alzheimer’s Disease (2014, background): “Innate immunity is activated both in cerebrovascular disease [27] and in AD, in which postmortem studies show chronic inflammation characterized by an influx of activated microglia and infiltrating monocytes around plaques and tangles [28].”