The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses.

By S. Hussain, David J. Yang, D. Suki, Kenneth D. Aldape, E. Grimm, A. Heimberger. Neuro-Oncology, 2006

600 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/56a9a3bfb4c97b7f11c855da10fec536e84f6dce

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In Immunology

In Neurology

Citations in the corpus

Comprehensive analyses of tumor immunity: implications for cancer immunotherapy (2016, unknown): “Macrophages are significantly enriched in GBM, which is supported by previous observations showing that microglia and macrophages are present in large numbers in the glioma microenvironment [21].”
Glioma cancer stem cells induce immunosuppressive macrophages/microglia. (2010, methodology): “T-cell proliferation was determined using a carboxyfluorescein diacetate succinimidyl ester (CFSE)-based assay,(51) which we have used previously.(12,25,26,40) In brief, healthy donor PBMCs were labeled with 2 mM CFSE for 5 minutes at room temperature in PBS, and then the reaction was quenched with ”
Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. (2008, background): “The cluster also contains probes encoding major histocompatibility complex class II surface molecules, but lacks expression of costimulatory molecules critical for T-cell activation.(33) This immune signature may be relevant for strategies of tumor vaccination.”
The microenvironmental landscape of brain tumors (2017, background): “…analysis of patient glioma tissue indicates that TAMs produce low levels of pro-inflammatory cytokines and lack expression of keymolecules involved in T cell co-stimulation (e.g., CD40, CD80, and CD86), suggesting that they are poor inducers of T cell responses in glioma (Hussain et al., 2006).”
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy (2017, result): “In contrast to the contradictory reports for lung and CRC, the presence of TAM in human gliomas seems to be exclusively associated with tumor growth, grade, and poor prognosis [70, 71].”