CNS immune privilege: hiding in plain sight

By M. Carson, Jonathan M. Doose, B. Melchior, C. Schmid, C. Ploix. Immunological Reviews, 2006

783 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/81f61d33a4b4ee6183ae90f43f94244d09b3e30e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. B. Barres
2. M. Sofroniew

In Neurology

1. G. Harry
2. C. McPherson
3. B. Barres
4. Rubén Orihuela
5. Jonathan Kipnis
6. M. Sofroniew
7. M. Pekny

Citations in the corpus

• A survey of human brain transcriptome diversity at the single cell level (2015, background): “Nonetheless, over the last few years there has been accumulating evidence in mouse that the CNS is immune competent as well as interactive with the immune system (22).”
• Microglial M1/M2 polarization and metabolic states (2016, background): “Similar to other tissue-specific resident macrophages, microglia represent 10–15% of the total cell population within the brain parenchyma (Carson et al., 2006) and display a level of morphological heterogeneity across regions (Lawson et al., 1990; Mittelbronn et al., 2001; Harry and Kraft, 2012).”
• Regulation of learning and memory by meningeal immunity: a key role for IL-4 (2010, background): “Vol. 207 No. 5 1067-1080 www.jem.org/cgi/doi/10.1084/jem.20091419 1067 Immune activity in the central nervous system (CNS) is restricted, primarily because of the blood–brain barrier (Hickey, 1999; Pachter et al., 2003; Carson et al., 2006; Bechmann et al., 2007).”