Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

By A. Mildner, Hauke Schmidt, M. Nitsche, D. Merkler, U. Hanisch, M. Mack, M. Heikenwalder, Wolfgang Brück, Josef Priller, Marco Prinz. Nature Neuroscience, 2007

1,079 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/b75c23791abcd4b529c593a42596f47f3ed111c0

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Citations in the corpus

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, positive): “Once established, microglia cells maintain themselves throughout adult life by virtue of longevity and limited self-renewal without input from definitive hematopoesis (Ajami et al., 2007; Ginhoux et al., 2010; Mildner et al., 2007).”
Immune activation in brain aging and neurodegeneration: too much or too little? (2009, methodology): “A complementary study also showed that bone-marrow-derived cells do not contribute to microglial populations unless the brain is irradiated (Mildner et al., 2007).”
The biphasic function of microglia in ischemic stroke (2017, neutral): “…induced by copper chelator cuprizone and a model of facial nerve axotomy in mice, blood derived Ly-6ChiCCR2+ monocytes could invade into the central nervous system and contribute to the repopulation of microglia after the brain was irradiated (Mildner et al., 2007; Varvel et al., 2012).”
CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain (2014, positive): “In contrast, the brain is separated from circulation by the BBB, and experiments have shown that there is little infiltration of peripheral HSCs/monocytes/macrophages into the CNS to help maintain or replenish microglia under normal, nonirradiated conditions (Ajami et al., 2011; Greter and Merad, 20”
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond (2009, background): “Indeed, stimulation of myogenesis to produce chronic muscle hypertrophy (by inhibition of the inhibitory hormone myostatin) provided no benefit in slowing disease (Holzbaur et al., 2006; Miller et al., 2006).”
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation (2019, background): “However, irradiation of the host primes the tissue and induces the artificial engraftment of donor-derived cells into the CNS (44, 45).”
Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress (2014, result): “This is in line with previous studies using lead shielding to protect the CNS from radiation (23).”
Origin and differentiation of microglia (2013, background): “Mildner showed that recipient mice in which the CNS was shielded to protect from the irradiation and its associated inflammation, which induces the release of pro-inflammatory cytokines and chemokines, did not experience a significant invasion of bone marrow-derived cells into the brain, in contrast”
Macrophages: development and tissue specialization. (2015, background): “Aside from epidermal LCs (170), microglia were the first cells of the innate immune system that were experimentally proven to be long-lived and independent of BM-derived myeloid cell replenishment during adulthood (171, 172).”