High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

By Dunja Mrdjen, Anto Pavlovic, F. Hartmann, B. Schreiner, Sebastian G. Utz, Brian P. Leung, I. Lelios, Frank Heppner, Jonathan Kipnis, D. Merkler and 2 more. Immunity, 2018

823 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/b0903c4c811f54c38107040c3450a8ca5e7de8f7

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Citations in the corpus

The blood–brain barrier in health and disease: Important unanswered questions (2020, background): “Single-cell sequencing has identified many subsets of immune cells with distinct roles in neuroinflammation that likely interact with the BBB in disease (Mrdjen et al., 2018; Jordão et al., 2019; Kierdorf et al., 2019; Masuda et al., 2019; Mundt et al., 2019).”
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation (2019, background): “Although pDCs expressed almost no RFP, ~30% of cDC1 and cDC2 were targeted in this line, which is in agreement with recent findings (13).”
Role of neuroinflammation in neurodegeneration development (2023, background): “However, recent studies using highdimensional single-cell analysis revealed that BAMs display regional heterogeneity and can be classified into multiple subtypes with diverse signatures.(515,516) Importantly, the special anatomical location of BAMs confers them unique function in CNS homeostasis.”
Developmental and Functional Heterogeneity of Monocytes. (2018, background): “In both cases, the number of circulating Ly6CLow monocytes decrease, while Ly6CHi monocyte numbers remain unaffected (Greter et al., 2012; Hoeffel et al., 2015; MacDonald et al., 2010; Mrdjen et al., 2018).”
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019, background): “These branching trajectories broadly match the old classification of microglia as resting (M0), proinflammatory (M1), and pro-resolution (M2) microglia, but they also indicate that microglial phenotypes are highly dynamic (Butovsky and Weiner, 2018; Friedman et al., 2018; KerenShaul et al., 2017; Mr”
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction (2018, positive): “…of Timd4 and Lyve1 expression in resident macrophages from other tissues suggests that they may represent important resident macrophage markers 38, 39, 40 , and specifically within the myocardium – TIMD4 and LYVE1 may be used to identify resident macrophages in the absence of dedicated…”