Autoimmune T cell responses in the central nervous system
By J. Goverman. Nature reviews. Immunology, 2009
1,042 citations recorded by the source corpus.
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by two distinct lineages of CD4+ T cells that are defined by the production of either interferon-γ or interleukin-17. The activity of these CD4+ T cell subsets within the CNS influences the pathology and clinical course of disease. New animal models show that myelin-specific CD8+ T cells can also mediate CNS autoimmunity. This Review focuses on recent progress in delineating the pathogenic mechanisms, regulation and interplay between these different T cell subsets in CNS autoimmunity.
Subfields: Immunology, Neurology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/9bbbb7ddde544e74b46276b54d7110e46a7bef01
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Citations in the corpus
- NF-κB signaling in inflammation (2017, neutral): “109 The involvement of NF-κ B signaling pathway in multiple sclerosis has been suggested by genome-wide association studies.”
- Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis (2010, background): “Multiple sclerosis (MS) is an autoimmune disease that affects the CNS (1).”
- MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. (2009, background): “cells determines lesion development (Fugger et al., 2009; Goverman, 2009; Steinman, 2009).”
- The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF (2011, neutral): “2031" language="eng" relation="no"> T helper type 1 cells (T H 1 cells) and interleukin 17 (IL-17)-producing helper T cells (T H 17 cells) are mediators of central nervous system (CNS) autoimmunity in both experimental autoimmune encephalomyelitis (EAE) and multiple sclerosi”
- Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “In contrast, about 10% of MS patients do not show any remission, and the primary neurological symptoms exhibit continuous so-called primary progression (Goverman, 2009; Sospedra and Martin, 2005).”