NALP1 in vitiligo-associated multiple autoimmune disease.

By Ying Jin, Christina M. Mailloux, Katherine Gowan, Sheri L. Riccardi, Greggory S. Laberge, D. Bennett, P. Fain, R. Spritz. New England Journal of Medicine, 2007

640 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/f5d4cdfbd44025202b501629f5e13c6bbbf53118

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. J. Tschopp
2. Kate Schroder
3. G. Núñez
4. M. Lamkanfi
5. V. Dixit
6. Fabio Martinon
7. L. Franchi
8. T. Kanneganti

In Molecular Biology

1. T. Kanneganti
2. J. Tschopp
3. M. Lamkanfi
4. G. Núñez
5. Kate Schroder
6. V. Dixit
7. S. Man
8. L. Franchi

In Physiology

1. G. Núñez
2. Kate Schroder
3. J. Tschopp
4. M. Lamkanfi
5. V. Dixit
6. L. Franchi
7. C. A. Dinarello

Citations in the corpus

• The Inflammasome: A Caspase-1 Activation Platform Regulating Immune Responses and Disease Pathogenesis (2009, background): “NLRP1 variants are associated with susceptibility to vitilig”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “The importance of NLRP1 is underscored by the finding that a locus containing NLRP1 is responsible for familial vitiligo, a chronic skin disorder characterized by a loss of pigmentation and association with a variety of autoimmune and autoinflammatory conditions such as hypothyroidism and rheumatoid”
• Inflammasomes and their roles in health and disease. (2012, background): “Because most identified SNPs in NLRP1 (including rs12150220) are located in and around the central NACHT domain, they are thought to reduce the threshold for inflammasome assembly and IL-1β production ( Jin et al. 2007b).”
• Regulation of inflammasome activation (2015, background): “In humans, genetic studies revealed that mutations in NLRP1 are linked to autoinflammatory diseases, including vitiligo and Addison’s disease (29).”
• The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation (2016, background): “…after infection with various viral and bacterial infectious agents, such as vaccinia virus, mouse cytomegalovirus (Rathinam et al., 2010), Francisella tularensis (FernandesAlnemri et al., 2010; Jones et al., 2010; Rathinam et al., 2010), and Listeria (Kim et al., 2010; Rathinam et al., 2010).”
• The inflammasomes: guardians of the body. (2009, background): “The role of inflammasomes in regulating the adaptive immune response is supported by the findings showing that polymorphisms in NALP1 are associated with vitiligo-associated multiple autoimmune disease (235), a disorder in which the patients, in addition to generalized vitiligo characterized by loss”
• Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). (2009, background): “One interesting example is the association of NLRP1 not only with vitiligo, but also with a range of other autoimmune diseases that affect the relatives of vitiligo probands (154).”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “demonstrated to contribute to the risk of vitiligo-associated multiple autoimmune diseases (160).”
• The inflammasomes. (2010, positive): “Mutations in NLRP1 are associated with vitiligo-associated multiple autoimmune disease (Jin et al., 2007).”
• Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. (2011, neutral): “to generalized vitiligo and other autoimmune diseases, such as autoimmune thyroid disease, pernicious anemia, systemic lupus erythematosus, and Addison disease.(127) Lastly, one study revealed that variant promoter regions of X-box binding protein 1 (XBP1) were associated with vitiligo in the Chines”