The Inflammasome: A Caspase-1 Activation Platform Regulating Immune Responses and Disease Pathogenesis

By L. Franchi, T. Eigenbrod, Raúl Muñoz-Planillo, G. Núñez. Nature Immunology, 2009

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The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC are critical components of the inflammasome that link microbial and endogenous 'danger' signals to caspase-1 activation. Several diseases are associated with dysregulated activation of caspase-1 and secretion of IL-1β. Thus, understanding inflammasome pathways may provide insight into disease pathogenesis that might identify potential targets for therapeutic intervention.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/be1504d5125b6614fcdd9f8bec093df0aada0eba

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Citations in the corpus

Cell Death Signaling. (2015, background): “ASC also contains a CARD that binds to and activates caspase-1 (Martinon et al. 2002; Faustin et al. 2007; Franchi et al. 2009).”
Pathogen Recognition by the Innate Immune System (2011, background): “Recently, several reports showed that the pathogenic fungus, Candida, and baker’s yeast (Saccharomyces) induced IL-1β via NLRP3, ASC and caspase-1, and further studies revealed that β-glucan, a major component of fungal cell walls, activates the NLRP3 inflammasome [108–115].”
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Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, neutral): “5) [221,222].”
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “The activation of inflammasomes, a group of intracellular multimeric protein complexes that activate inflammatory caspase-1, is a major inflammatory pathway [2].”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “Thus, pyroptosis is often (if not always) associated with IL-1β and IL18 secretion, and hence mediates robust pro-inflammatory effects [614, 615].”
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