The inflammasomes.

By Kate Schroder, J. Tschopp. Cell, 2010

4,636 citations recorded by the source corpus.

Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway in tailoring immune responses. Here, we comprehensively review mechanisms directing normal inflammasome function and its dysregulation in disease. Agonists and activation mechanisms of the NLRP1, NLRP3, IPAF, and AIM2 inflammasomes are discussed. Regulatory mechanisms that potentiate or limit inflammasome activation are examined, as well as emerging links between the inflammasome and pyroptosis and autophagy.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ec9194f37491ad7f63758578321b28cfc45528c8

How researchers see this paper

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In Immunology

1. Katherine A. Fitzgerald
2. Jesús Gil
3. D. Su
4. Wenjun Ouyang
5. Min Huang
6. Judy H. Cho
7. D. Underhill
8. P. Jat

In Molecular Biology

1. Jesús Gil
2. D. Su
3. T. Simmet
4. Katherine A. Fitzgerald
5. D. Underhill
6. P. Jat
7. R. Flavell
8. D. Couchie

Citations in the corpus

• NLRP3 inflammasome and its inhibitors: a review (2015, methodology): “Formation of the inflammasome also triggers a process of inflammation-related cell death termed pyroptosis (Willingham et al., 2009; Schroder and Tschopp, 2010; Zhong et al., 2013a; Jorgensen and Miao, 2015).”
• Senescence and the SASP: many therapeutic avenues (2020, background): “Inflammasomes are groups of pattern recognition receptors (PRR) capable of recognizing different DAMPs and activating the IL-1 inflammatory cascade or inducing pyroptosis (Schroder and Tschopp 2010).”
• Pathophysiology of Atherosclerosis (2022, background): “CD36-mediated oxLDL uptake activates the NLRP3 inflammasome, resulting in the robust secretion of the inflammatory cytokine IL-1β36 [252].”
• IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine (2012, positive): “Inflammasomes typically assemble with the adaptor protein ASC (apoptosis-associated speck-like protein) into a multiprotein complex that leads to caspase1 activation and subsequent cleavage of pro-IL-18 (or pro-IL-1) 23 .”
• NLRP6 inflammasome is a regulator of colonic microbial ecology and risk for colitis (2011, neutral): “Inflammasomesare cytoplasmic multiprotein complexes that are composed of one of several NLR proteins, including NLRP1, NLRP3, and NLRC4, which function as sensors of endogenousor exogenous stress or damage-associated molecular patterns (Schroder and Tschopp, 2010).”