The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
By D. Sharma, T. Kanneganti. Journal of Cell Biology, 2016
649 citations recorded by the source corpus.
Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.
Subfields: Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/9879227dc782d9f2effa75448dffd871fa6e9352
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In Molecular Biology
Citations in the corpus
- Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “Inflammasomes drive inflammation and pyroptosis The inflammasome is a multiprotein complex, which is attributed to the production and release of inflammatory cytokines, IL-1β and IL-18.(286,287) Recent work reveals that inflammasome is involved in pyroptosis dependent on the cleavage of Gasdermin D,”
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “There are five members of PRRs that have been confirmed to form inflammasomes: the nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR)-containing proteins (NLR) family members NLRP1, NLRP3, and NLRC4, as well as absent-in-melanoma 2 (AIM2) and pyrin [3,4].”