A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

By M. Cargill, Steven J. Schrodi, Monica Chang, Veronica E. Garcia, R. Brandon, Kristina P. Callis, N. Matsunami, Kristin G. Ardlie, D. Civello, J. Catanese and 10 more. American Journal of Human Genetics, 2007

1,138 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/f3158c0231bb5ad4bed76465c5decfd7dcfcf49f

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In Immunology

1. D. Cua
2. V. Kuchroo
3. T. Korn
4. M. Oukka
5. E. Bettelli
6. R. Kastelein
7. Brent S. McKenzie
8. T. Mcclanahan

Citations in the corpus

• IL-17 and Th17 Cells. (2009, result): “Similarly, other genome-wide association studies (93, 94) revealed associations of IL23R gene SNPs [R381Q: rs11209026 (same as in Crohn’s disease) and L310P: rs7530511] with psoriasis, further strengthening the idea that IL-23R may be involved in inducing human autoimmune diseases.”
• A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 (2010, neutral): “2q24 rs17716942 162,968,937 IFIH1 (5) A 0.”
• Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells (2009, background): “Moreover, studies of genetic risk factors suggest that IL-23 is involved in psoriasi”
• Skin immune sentinels in health and disease (2009, neutral): “Interestingly, variants in the T H 17 cell-associated genes IL23A , IL12B and IL23R”
• Development, cytokine profile and function of human interleukin 17–producing helper T cells (2007, background): “Moreover, a genome-wide screen has identified the gene encoding IL-23R as a 'psoriasis-susceptibility gene”
• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “Recently, a critical role of IL-23 in the pathogenesis of psoriasis was indicated on the basis of both genetic-association study and human clinical data (Cargill et al., 2007; Kauffman et al., 2004; Krueger et al., 2007; Lee et al., 2004).”
• Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility (2011, background): “, and variants within IL12B and IL23R have been associated with both Crohn's disease and psoriasi”
• The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “In addition, we and others have also shown that the IL12B gene, coding for the IL-12p40 subunit of IL-12 and IL-23, is associated with psoriasis (Capon et al., 2007; Cargill et al., 2007).”