Skin immune sentinels in health and disease

By Frank O. Nestle, P. Di Meglio, J. Qin, B. Nickoloff. Nature reviews. Immunology, 2009

1,353 citations recorded by the source corpus.

Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103+ dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.

Subfields: Dermatology, Immunology

View Paper: https://www.semanticscholar.org/paper/94e4c515590e646285acf5c529e5067dbe9acc77

How researchers see this paper

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In Dermatology

1. J. Krueger
2. M. Suárez‐Fariñas

In Immunology

1. K. Palucka
2. Jacques Banchereau
3. J. Krueger
4. M. Lowes
5. M. Suárez‐Fariñas

Citations in the corpus

• Immunology of Psoriasis (2014, background): “Figure 1b diagrams how the epidermis may participate in innate or adaptive immune responses, either by directing migration of new T cell subsets into the skin through production of cytokines or by increased synthesis of innate effector molecules directly in keratinocytes (5).”
• Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “Studies of human cutaneous DCs demonstrated their phenotypic and functional heterogeneity (Klechevsky et al., 2008; Nestle et al., 2009; Joffre et al., 2012).”