Regulated portals of entry into the cell

By Sean D. Conner, S. Schmid. Nature, 2003

3,840 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f19acb0ee3c8ffec787d7bb621d1540e7764dd70

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Citations in the corpus

Subcellular targeting strategies for drug design and delivery (2010, neutral): “This endocytic route engages mainly receptor–ligand complexe”
Immunological properties of engineered nanomaterials (2007, background): “Uptake mechanisms Mammalian cells have five ways to internalize macromolecules and/or nanoparticles: phagocytosis (via mannose receptor-, complement receptor-, Fcγ receptor, and scavenger receptor-mediated pathways), macropinocytosis, clathrin-mediated, caveolin-mediated, and clathrin/caveolin-in”
Endocytosis of Nanomedicines (2010, background): “It is responsible for uptake of essential nutrients like cholesterol carried into cells by low density lipoprotein (LDL) via the LDL receptor, or iron carried by transferrin (Tf) signaling by internalization and degradation of receptors andmaintaining cellular homeostasis, for example, by traffickin”
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins (2009, background): “Given our understanding of canonical vesicle budding mediated by cytosolic coat”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “There are multiple pathways that can mediate endocytosis, including phagocytosis, macropinocytosis, clathrin-mediated endocytosis, caveolae-mediated endocytosis, and clathrin- and caveolae-independent endocytosis [221].”
Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. (2010, background): “When the putative cytotoxicity of nanoparticles is determined, it is prudent to consider whether cells do in fact encounter individual nanoparticles, as opposed to aggregates or agglomorates of several nanoparticles; this becomes particularly relevant when studying cellular recognition and internali”
Pathways and mechanisms of endocytic recycling (2009, neutral): “Endocytosis occurs by various mechanisms, which can be divided into those that are clathrin dependent and those that are clathrin independen”
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells (2006, background): “Total internal reflection microscopy and immuno-electron microscopy revealed that flotillin-1-containing regions of the plasma membrane seem to bud into the cell, and are distinct from clathrin-coated pits and caveolin-1-positive caveola”
Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (2006, background): “The ruffling response is also dependent on protein kinase C (Conner and Schmid, 2003).”
Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity (2012, background): “Phagocytosis is an energy- and receptor-dependent uptake process involving invagination of the plasma membrane and subsequent fusion with lysosomes [12].”
Heavy metal bioaccumulation and toxicity with special reference to microalgae (2008, background): “Heavy metal ions can cause plasma membrane depolarization and acidification of the cytoplasm (Cardozo et al., 2002; Conner and Schimid, 2003 ).”
Rab conversion as a mechanism of progression from early to late endosomes. (2005, background): “The endocytic system of eukaryotic cells embraces a complex network of membrane compartments, each fulfilling a specific set of tasks in cargo sorting, distribution, and catabolism (for review, see Conner and Schmid, 2003; Gruenberg and Maxfield, 1995; Mellman, 1996; Pelkmans and Helenius, 2003).”
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine. (2019, background): “Caveolae are flask-shaped vesicles with diameters of 50-100 nm that are stabilized by a caveolin protein based coat [48].”
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? (2010, positive): “The 1‐100 nm scale is of interest for biological interfaces; for example, objects less than 12 nm in diameter may cross the blood‐brain barrier (Oberdorster et al. 2004; Sarin et al. 2008; Sonavane et al. 2008), and objects of 30 nm or less can be endocytosed by cells ( Conner and Schmid 2003 ).”