Rab conversion as a mechanism of progression from early to late endosomes.

By J. Rink, E. Ghigo, Y. Kalaidzidis, Marino Zerial. Cell, 2005

1,690 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/6e7f92ca1272a56e7f642cd25d5746b21e7a4104

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In Cell Biology

1. M. von Zastrow
2. Ari Helenius
3. Jatta Huotari
4. Pier Paolo Di Fiore
5. Harald A. Stenmark
6. Ivo F. Sbalzarini
7. P. Saftig
8. P. Novick

In Molecular Biology

1. M. von Zastrow
2. Pier Paolo Di Fiore
3. Ari Helenius
4. Jatta Huotari
5. Erik H. W. Meijering
6. Harald A. Stenmark
7. P. Novick
8. F. Sánchez‐Madrid

In Surgery

1. M. von Zastrow
2. Ari Helenius
3. Jatta Huotari
4. Pier Paolo Di Fiore
5. V. Deretic

Citations in the corpus

• Lysosomes: fusion and function (2007, background): “Recent live-cell imaging studies have reconciled mechanistic aspects of both models, with the observation that large (400–800 nm) vesicles arise from a dynamic early endosome network and undergo a conversion in which they lose the small GTPase RAB5 and recruit RAB7 (Ref”
• Rab GTPases as coordinators of vesicle traffic (2009, background): “Such conversion has been elegantly shown in the case of the maturation of RAB5-positive early endocytic structures into later RAB7-positive structures, which involves the RAB5-mediated recruitment of the HOPS complex, in which the VPS39 subunit is a RAB7 GE”
• Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking (2008, background): “In mammalian cells, hVps39 regulates the recruitment/activation of Rab7 onto the Rab5-labelled early endosomes, a process called Rab conversio”
• Role of Rab GTPases in Membrane Traffic and Cell Physiology (2011, background): “These data suggest a maturation model whereby each transport compartment gains the necessary factors to move forward along the pathway while losing those that define the previous compartment (340).”
• Identification of the switch in early-to-late endosome transition. (2010, methodology): “The Class C VPS/HOPS complex has been shown to be present on maturing endosomes and can interact with Rab5-GTP (Rink et al., 2005).”
• Syndecan–syntenin–ALIX regulates the biogenesis of exosomes (2012, background): “Note that truncated forms of Alix containing the V domain interact with the two parts of the N-Ter domain of syntenin that contain LYPXL motifs, (1-30) and (31-60), and that mutation of the three LYPXL motifs (YP to AA) abolishes the interaction.”
• Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. (2007, background): “Interestingly, human homologs of Vps11p, Vps16p, and Vps18p are also components of a mammalian complex that binds to Rab5-GTP (Rink et al., 2005).”
• Objective comparison of particle tracking methods (2014, methodology): “METHOD 4: PARAMETERS The user parameters of this method (and typical values) are:  Number of iterations of convolution with the Gaussian kernel (10-500).”
• Regulation of small GTPases by GEFs, GAPs, and GDIs. (2013, background): “Cascades of endocytic Rabs, in which activated Rabs recruit effectors that act as GAPs for the previous Rab (251) or as GEFs for the next Rab (249), are now an established feedforward component of Rab signaling (reviewed in Ref.”
• Endosome maturation (2011, methodology): “…its guanine-nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), GDP dissociation inhibitors (GDIs), and GDI displacement factors (GDFs) as well as its effectors determine the functions of EEs (Chavrier et al, 1990; Ullrich et al, 1994; Rink et al, 2005; Jovic et al, 2010).”