Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

By O. Glebov, N. Bright, B. Nichols. Nature Cell Biology, 2006

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Endocytosis of Nanomedicines (2010, background): “As an alternative the use of siRNA that can knockdown specific endocytic proteins is becoming increasingly popular [14].”
The Calcium Channel α2δ-2 Subunit Partitions with CaV2.1 into Lipid Rafts in Cerebellum: Implications for Localization and Function (2006, background): “However, it is of interest that a role for the related lipid raft protein flotillin in endocytosis has recently been defined (Glebov et al., 2006).”
Pathways of clathrin-independent endocytosis (2007, methodology): “Using a fluorescence resonance energy transfer ( FRET )-based assay, Nichols and colleagues have shown that CtxB is not significantly clustered when it is located in clathrin-coated pits, whereas considerable clustering is observed in other parts of the membran”
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls. (2010, background): “Flotillin dependent endocytosis was recently characterized as a dynamin-2, caveolin-1 and clathrin independent pathway [17].”
Function and regulation of human copper-transporting ATPases. (2007, background): “It is possible that ATP7A may utilize flotillin-1, a recently discovered protein that defines a novel clathrinindependent pathway in mammalian cells (77).”