Pathways and mechanisms of endocytic recycling

By B. Grant, J. Donaldson. Nature reviews. Molecular cell biology, 2009

1,490 citations recorded by the source corpus.

Endocytic recycling is coordinated with endocytic uptake to control the composition of the plasma membrane. Although much of our understanding of endocytic recycling has come from studies on the transferrin receptor, a protein internalized through clathrin-dependent endocytosis, increased interest in clathrin-independent endocytosis has led to the discovery of new endocytic recycling systems. Recent insights into the regulatory mechanisms that control endocytic recycling have focused on recycling through tubular carriers and the return to the cell surface of cargoes that enter cells through clathrin-independent mechanisms. Recent work emphasizes the importance of regulated recycling in processes as diverse as cytokinesis, cell adhesion, morphogenesis, cell fusion, learning and memory.

Subfields: Cell Biology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/81989f4b62d95b47b9feada73aa8a885c497977b

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Citations in the corpus

• Arf Family G Proteins and their regulators: roles in membrane transport, development and disease (2011, background): “Recycling endosomes return membrane proteins that are important for cell adhesion and migration back to the plasma membrane 34, 35 .”
• Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “Within the endosomal system or endocytic pathway, the endosomes are divided into different compartments—early endosomes, late endosomes , and recycling endosomes (Grant and Donaldson 2009).”
• Insight into nanoparticle cellular uptake and intracellular targeting (2014, neutral): “In addition, the cargo can be routed to the trans-Golgi network or recycled back to the plasma membrane [59].”
• TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling (2020, background): “Fast recycling involves Rab4- or Rab35-marked vesicles which bud off of the early endosomes and next fuse with the plasma membrane [204].”
• Fusion Protein Linkers: Property, Design and Functionality (2012, background): “The binding to hGHR led to endocytosis and lysosomal degradation of the fusion proteins as evidenced by the prolonged plasma half-life of three hGH-Tf proteins after blocking their hGHR binding with excess hGH (Table 4), similar to previous reports for free hGH [80, 81].”
• Molecular mechanism and physiological functions of clathrin-mediated endocytosis (2011, background): “When cargo has been taken up, it is sorted in endosomes and either sent back to the surface or targeted to more mature endosomes and later compartments (such as lysosomes and multivesicular bodies”