The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

By C. Raiborg, Harald A. Stenmark. Nature, 2009

1,421 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/ce553a39e195bcca1f4291de2a2d28a11f864e85

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Ivan Dikic
2. G. Raposo
3. C. Théry
4. Marina Colombo
5. F. Sánchez‐Madrid
6. M. Wood
7. W. Henne
8. Ari Helenius

In Epidemiology

1. Marina Colombo
2. M. Wood
3. F. Cecconi
4. Ari Helenius
5. Ivan Dikic
6. Jatta Huotari
7. P. Saftig
8. G. Raposo

In Physiology

1. Marina Colombo
2. M. Wood
3. W. Henne
4. F. Cecconi
5. Ari Helenius
6. Ivan Dikic
7. Jatta Huotari
8. C. Théry

Citations in the corpus

• Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles (2013, background): “The discovery that the ESCRT machinery is involved in MVB formation (Henne et al., 2011; Raiborg and Stenmark, 2009) opened a new avenue to interfere with the formation of ILVs and thereby exosome secretion.”
• Syndecan–syntenin–ALIX regulates the biogenesis of exosomes (2012, background): “Note that truncated forms of Alix containing the V domain interact with the two parts of the N-Ter domain of syntenin that contain LYPXL motifs, (1-30) and (31-60), and that mutation of the three LYPXL motifs (YP to AA) abolishes the interaction.”
• mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6 (2013, methodology): “(d) HEK293 cells were co-transfected with vectors encoding AMBRA1 together with ULK1–Myc FL (full length) or its deletion mutants encoding the kinase and the proline-rich domains (1829–1,051), and the ULK1 carboxy-terminal domain (11-828).”
• Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, background): “Interestingly, exosome biogenesis (15,16), protein cargo sorting (17,18) and release (19) involve the endosomal sorting complex required for transport (ESCRT complex) and other associated proteins such as Alix (20,21) and Tsg101 (22).”
• Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis (2013, neutral): “CHMP2B is a core component of endosomal sorting complexes (reviewed in Raiborg and Stenmark, 2009) (Figure 5E).”
• Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “Exosome biogenesis depends on the endosomal sorting complex required for transport (ESCRT) machinery that is responsible for protein sorting and ILV formation (50, 51).”
• The ESCRT pathway. (2011, background): “For more in-depth discussion, the reader should refer to several reviews that focus on ESCRT structure, ESCRT roles in diseases, the ubiquitin cycle, and vesicle budding (Hurley et al., 2010; Raiborg and Stenmark, 2009; Saksena and Emr, 2009; Williams and Urbé, 2007).”
• The tetraspanin CD63 regulates ESCRT-independent and dependent endosomal sorting during melanogenesis (2011, background): “…many physiological processes including cessation of growth factor signaling, lysosomal degradation, exosome secretion, lysosome related organelle (LRO) biogenesis, and perhaps even amyloid formation (Raiborg and Stenmark, 2009; Raposo et al., 2007; Simons and Raposo, 2009; van Niel et al., 2006).”