Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?
By Alaaldin M. Alkilany, C. Murphy. Journal of nanoparticle research, 2010
1,484 citations recorded by the source corpus.
Gold nanoparticles have attracted enormous scientific and technological interest due to their ease of synthesis, chemical stability, and unique optical properties. Proof-of-concept studies demonstrate their biomedical applications in chemical sensing, biological imaging, drug delivery, and cancer treatment. Knowledge about their potential toxicity and health impact is essential before these nanomaterials can be used in real clinical settings. Furthermore, the underlying interactions of these nanomaterials with physiological fluids is a key feature of understanding their biological impact, and these interactions can perhaps be exploited to mitigate unwanted toxic effects. In this Perspective we discuss recent results that address the toxicity of gold nanoparticles both in vitro and in vivo, and we provide some experimental recommendations for future research at the interface of nanotechnology and biological systems.
Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/a342839c99e5843e2ed475a6f1d435d088dfde89
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomaterials
In Electronic, Optical and Magnetic Materials
Citations in the corpus
- Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment (2017, background): “Similar to bulk gold, AuNPs are generally considered to be chemically inert and biocompatible.(35) However, upon intravenous administration, AuNPs are rapidly coated with serum proteins that alter their biological identity and change how they are presented to cells.”
- Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems (2022, background): “Surface functionalization is one of the most favorable properties of Au NPs in the biomedical domain [171].”
- Metal-Based Nanoparticles as Antimicrobial Agents: An Overview (2020, background): “On the other hand, some researches have reported the non-toxicity of the AuNPs in vitro testing different cell lines, nanoparticle shape and surface groups, and doses [145].”