Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.

By Yang-ja Lee, Seon‐Yong Jeong, M. Karbowski, Carolyn L. Smith, R. Youle. Molecular Biology of the Cell, 2004

1,097 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/efe0129500273573f3c3607fd3fceb910f1cd9d0

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Citations in the corpus

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. (2006, positive): “Expression of a dominant negative mutant of DRP-1 or downregulation of hFis1 in Cell 126, 177–189, July 14, 2006 ª2006 Elsevier Inc. 177 mammalian cells delays cytochrome c release and apoptosis (Frank et al., 2001; Lee et al., 2004).”
Mitochondrial fusion and fission in cell life and death (2010, background): “Furthermore, knockdown of human FIS1 does not affect the distribution of DRP1 in mitochondri”
The role of mitochondria in apoptosis. (2008, background): “ponents of the mitochondrial fusion machinery, Mfn1 and 2 (98, 99) and Opa1 (77, 97), resulted in the increased mitochondrial fragmentation and increased sensitivity to apop-”
Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Mitochondria are regarded as significant cellular drivers and mediators of the inflammatory process [179].”
The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “These opposing processes determine the architecture of the entire mitochondrial population of the cell and influence nearly every aspect of mitochondrial functions, including respiration, calcium buffering, and apoptosis (1, 2, 28, 51, 100).”
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission (2013, background): “…of Fis1 in mammalian cells promotes fragmentation of mitochondria (Yoon et al., 2003; Stojanovski et al., 2004; Yu et al., 2005), and inhibition of Fis1 results in elongation (Yoon et al., 2003; Lee et al., 2004; Stojanovski et al., 2004; Koch et al., 2005; Gandre-Babbe and van der Bliek, 2008).”
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases (2009, background): “In mammalian cells, however, knockdown of Fis1 blocks mitochondrial fission without affecting Drp1 localization to mitochondria (23).”
Mitochondrial fragmentation in neurodegeneration (2008, background): “The role of the mammalian homologue of Fis1, hFIS1, in recruitment of DRP1 to the mitochondria is less clear, because DRP1 cycling in and out of contact with mitochondria does not require hFIS1 (Ref”
Mitochondrial fusion and fission in mammals. (2006, background): “However, efficient knockdown of Fis1 does not affect Drp1 recruitment (Lee et al. 2004).”
The BCL-2 Family Reunion (2010, background): “Likewise, overexpression of DRP-1 or downregulation of OPA-1 induces mitochondrial fragmentation, but not apoptosis; classical inducers of apoptosis can also trigger cytochrome c release before mitochondrial fission (Arnoult et al., 2005; Karbowski et al., 2002; Lee et al., 2004).”