Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
By O. Loson, Zhiyin Song, Hsiuchen Chen, D. C. Chan. Molecular Biology of the Cell, 2013
1,157 citations recorded by the source corpus.
Mitochondrial fission requires recruitment of the GTPase Drp1 to mitochondria, but the molecules that mediate this recruitment have been disputed. Fis1, Mff, MiD49, and MiD51 can all recruit Drp1 to mitochondria and promote fission. MiD49 and MiD51 can promote mitochondrial fission, but their activity depends on cellular context.
Subfields: Clinical Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3ddd449b77827f56152005cb28abcddba8f046d6
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In Clinical Biochemistry
- Prashant Mishra
- A. M. van der Bliek
- Orian Shirihai
- M. Liesa
- S. Kawajiri
- Qinfang Shen
- D. C. Chan
- W. Ding
In Molecular Biology
- Prashant Mishra
- M. Liesa
- Orian Shirihai
- A. M. van der Bliek
- W. Ding
- D. C. Chan
- S. Kawajiri
- Qinfang Shen
Citations in the corpus
- Mitochondrial dynamics and mitochondrial quality control (2014, background): “Mitochondrial fission and fusion and motility in mitophagy Mitochondria are dynamic organelles that continuously undergo fission and fusion, which are necessary for cell survival and adaptation to changing conditions needed for cell growth, division, and distribution of mitochondria during…”
- Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “MiD49 and MiD51 have been recently described to recruit Drp1 to the mitochondria, although the role of MiD49- and MiD51-mediated recruitment in mitochondrial fission is still under investigation (Palmer et al., 2011; Losón et al., 2013).”
- Mechanisms of mitochondrial fission and fusion. (2013, result): “This was confirmed in a recent paper showing that Fis1, Mff, Mid49, and Mid51/Mief act in a partially redundant way to promote Drp1-dependent fission (Loson et al. 2013).”
- Metabolic regulation of mitochondrial dynamics (2016, background): “In cultured cells, Mff appears to be the primary receptor, because loss of Mff results in dramatic mitochondrial elongation (Gandre-Babbe and van der Bliek, 2008; Otera et al., 2010; Losón et al., 2013).”