The BCL-2 Family Reunion

By J. Chipuk, T. Moldoveanu, F. Llambi, Melissa J Parsons, Douglas R. Green. Molecules and Cells, 2010

1,486 citations recorded by the source corpus.

B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/01b7d3da16e00c8732c46c1c08b173359b4c9374

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In Molecular Biology

In Pathology and Forensic Medicine

Douglas R. Green

Citations in the corpus

Mitochondria: In Sickness and in Health (2012, background): “The lateral organization of the OM is not as well understood, but it serves as a unique signaling platform for pathways such as BCL-2 protein-dependent apoptosis (Chipuk et al., 2010; Bogner et al., 2010) and innate antiviral immunity, which requires the regulated self-assembly of the mitochondrial ”
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA (2014, background): “Bax/Bak-Dependent Induction of Type I IFNs The intrinsic pathway of apoptosis is activated upon MOMP by the Bax/Bak channel (Jiang and Wang, 2004).”
Bax, Bak and beyond — mitochondrial performance in apoptosis (2018, background): “After MOMP, caspase activation takes place often within minutes, leading to cell death [4, 5].”
Mitochondria and cell death: outer membrane permeabilization and beyond (2010, background): “Pulling the trigger: activation of MOMP BCL-2-mediated regulation of MOMP is discussed only briefly here, and the reader is referred to recent, extensive reviews for further detail”
Crosstalk between apoptosis, necrosis and autophagy. (2013, background): “BCL-2 family members regulate the mitochondrial pathway of apoptosis by complex interactions that determine the integrity of the outer mitochondrial membrane [60,61].”
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy (2015, neutral): “After this incubation, we permeabilize, stain with the fluorescent dye JC-1 and expose the cells to different BH3 peptides that will promote mitochondrial depolarization and MOMP, the ultimate event that triggers apoptosis.”
Cell Death Signaling. (2015, background): “Bcl2 proteins also control several other cellular processes, including mitochondrial fusion, autophagy, and calcium efflux from the ER (Chipuk et al. 2010).”
To be or not to be? How selective autophagy and cell death govern cell fate. (2014, positive): “…Bcl-2 homology domains) function to antagonize the antiapoptotic Bcl-2 proteins (the ''sensitizer/derepressors'') and/or to activate the proapoptotic effectors (the latter activity is a property of only a subset of these, the ''direct activators,'' notably Bid, Bim, and Puma) (Chipuk et al., 2010).”