Gene regulation mediated by calcium signals in T lymphocytes

By S. Feske, J. Giltnane, R. Dolmetsch, Louis Staudt, Anjana Rao. Nature Immunology, 2001

620 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e1fc0fdc24719b50d8f6b8ab4af5508425f0c6ee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Prakriya
2. R. Lewis
3. S. Feske
4. P. Hogan
5. Anjana Rao
6. Jie Zheng
7. M. Trudeau
8. F. Macian

In Molecular Biology

1. R. Lewis
2. S. Feske
3. M. Prakriya
4. P. Hogan
5. Michael E. Greenberg
6. Anjana Rao
7. F. Macian
8. Heike Wulff

In Physiology

1. S. Feske
2. M. Prakriya
3. R. Lewis
4. Anjana Rao
5. P. Hogan
6. Heike Wulff
7. E. Skolnik
8. A. Parekh

Citations in the corpus

• Handbook of ion channels (2015, background): “The abrogation of CRAC channel function in these cells results in the elimination of Ca2+ elevations necessary to drive nuclear translocation of NFAT [48], an important and widely expressed transcription factor involved in cytokine gene expression [67].”
• Transcriptional mechanisms underlying lymphocyte tolerance. (2002, positive): “As expected (Teague et al., 1999; Glynne et al., 2000; Feske et al., 2001), genes upreguby 70% the induction of IL-4, IL-5, and IL-13 mRNAs”
• Regulation of transcription factors by neuronal activity (2002, positive): “Although other NFAT targets in the CNS remain to be characterized, a study showing that most calcium-activated gene expression in lymphocytes is dependent on calcineurin activity indicates that NFAT might have a general role in calcium-induced gene expressio”
• Store-Operated Calcium Channels. (2015, positive): “A critical and widespread function of SOCE is to control gene expression through Ca(2) -sensitive transcription factors such as NFAT (102).”
• The functional network of ion channels in T lymphocytes (2009, background): “As described elsewhere in this volume, gene expression array profiling of control and SCID patient T cells reinforced the central role of Ca signaling and CRAC channel function in T-cell activation (195).”
• T-cell-antigen recognition and the immunological synapse (2003, background): “cgi?Q=nfatc%20not%207124&ORG=Hs">NFAT ) — a transcription factor that is responsible for many of the gene-expression changes associated with activated T H cell”
• Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance (2008, background): “T cells from patients of all three families show almost no store-operated Ca 2+ entry or CRAC channel function and, as a result, fail to proliferate in response to TCR stimulation in vitro”
• Ion Channels in Innate and Adaptive Immunity (2015, background): “expression in ORAI1-deficient human T cells is severely dysregulated, with a profound defect in key T cell cytokines such as IL-2, IL-4, IL-10, IFN-γ, and TNF-α (155, 167).”
• NFAT proteins: key regulators of T-cell development and function (2005, background): “Indeed, the analysis of gene expression using DNA microarrays has clearly shown that the activation-induced expression of most genes in T cells is blocked by calcineurin inhibitor”
• TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration (2008, background): “It seems that increases in intracellular Ca 2+ concentration ([Ca 2+ ] i ) control the production of certain cytokines, including interleukin-2 (IL-2) in T cell”
• Transcriptional regulation by calcium, calcineurin, and NFAT. (2003, background): “…been found by DNA array analyses: For instance, transcriptional profiling of T cells from control individuals and from patients with a primary defect in store-operated Ca2+ entry revealed that almost as many genes are repressed as are activated by Ca2+/calcineurin signaling (Feske et al. 2001).”
• STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1 (2009, positive): “respectively, and are required for T cell activation and mast cell degranulation ( Feske et al., 2001, 2005; Partiseti et al., 1994; Vig et al., 2008).”
• Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI (2010, background): “This was traced to an almost complete loss of store-operated Ca2+ entry and CRAC channel current, resulting in very minor, transient dephosphorylation and nuclear translocation of NFAT in stimulated T cells (79, 80, 90).”
• Store-operated calcium channels. (2005, positive): “In two studies on human patients, severe combined immunodeficiency has been linked to a loss of storeoperated Ca entry in T lymphocytes (86, 275).”