Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

By M. Oh‐hora, Megumi Yamashita, P. Hogan, Sonia Sharma, E. Lamperti, Woo-Chan Chung, M. Prakriya, S. Feske, Anjana Rao. Nature Immunology, 2008

623 citations recorded by the source corpus.

Subfields: Immunology, Physiology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/6443e618e4e905f21ca6a4e4f25d4ee45d7435c6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Feske
2. M. Prakriya
3. R. Lewis
4. P. Hogan
5. Anjana Rao
6. G. Lee
7. Angelika Schmidt
8. P. Krammer

In Physiology

1. M. Prakriya
2. R. Lewis
3. Anjana Rao
4. S. Feske
5. P. Hogan
6. Heike Wulff
7. E. Skolnik
8. Angelika Schmidt

In Sensory Systems

1. R. Lewis
2. M. Prakriya
3. S. Feske
4. Heike Wulff
5. E. Skolnik
6. Anjana Rao
7. P. Hogan
8. Angelika Schmidt

Citations in the corpus

• Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “In line with that, mice with CD4+ T cell-specific double deficiency of STIM1 and STIM2 display massive T cell proliferation despite undetectable store-operated Ca2+ influx (Oh-Hora et al., 2008).”
• Store-Operated Calcium Channels. (2015, positive): “However, autoimmunity and Treg deficiencies are not always seen in SOCE-deficient animal models, for example, in the Orai1 / or STIM1 / mice where Treg numbers are in the normal range (233, 269).”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “Attenuated TCR signals, caused by deficiency or mutation of TCR signaling components, such as Zap70 [13], LAT [14,15], PLCγ1 [16], STIM [17], DAG [18,19], Raf [20,21], or NF-κB [22–25], results in defective tTreg cell development.”
• Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI (2010, methodology): “Together, these findings suggest that store-operated Ca2+ entry through the STIM-Orai1 pathway is essential for Treg development and function (15), a finding confirmed in Stim1-null bone marrow chimeras generated independently by another group (228).”
• Ion Channels in Innate and Adaptive Immunity (2015, methodology): “A strong reduction of thymic nTreg numbers has been observed before in Stim1fl/fl Stim2fl/fl Cd4-Cre mice, which develop a myelo- and lymphoproliferative phenotype with age (131).”
• The transcription factor NFAT promotes exhaustion of activated CD8+ T cells (2015, neutral): “Fos and Jun are elevated only transiently after stimulation (Jain et al., 1992), whereas NFAT can remain in the nucleus for long times even in response to very low elevations of intracellular Ca2+ (Dolmetsch et al., 1997; Marangoni et al., 2013; Oh-Hora et al., 2008).”