T-cell-antigen recognition and the immunological synapse

By J. Huppa, Mark M. Davis. Nature reviews. Immunology, 2003

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Rafts defined: a report on the Keystone symposium on lipid rafts and cell function Published, JLR Papers in Press, April 27, 2006. (2006, background): “At the other end of the scale, large complexes such as the immunological synapse (5), thought to be derived from the coalescence of multiple smaller domains, were deemed too large and too complex to be considered as “simple” membrane rafts.”
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76 (2005, background): “Such interactions takes place through the formation of a specific structure at the interface: the 'immunological synapse”
Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment (2019, background): “The structure of an IS is highly organized with key interacting molecules organized in distinct areas called supra-molecular activation complexes (SMACs) (68).”