NFAT proteins: key regulators of T-cell development and function

By F. Macian. Nature reviews. Immunology, 2005

1,590 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6030714e5f20380aea322a4381c93fadd70dc661

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Citations in the corpus

The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells1 (2006, background): “Inositol trisphosphate triggers the cytoplasmic release of Ca(2) , which induces the translocation of NF-AT transcription factors to the nucleus, while diacylglycerol activates PKC and Ras guanyl-releasing protein, which in turn activate the Ras-ERK1/2 pathway and AP-1 nuclear translocation (4, 5).”
Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1 (2008, background): “Vav1 associates with the membrane in a PI3K-independent mechanism (39) and is known to potently induce activation of NFAT, NF- B, and AP1 (40).”
Differentiation of Effector CD4 T Cell Populations (2010, positive): “The NFAT family consists of five members, of which four, NFAT1 (also known as NFATp, NFATc2), NFAT2 (NFATc, NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATx, NFATc3), are regulated by calcium and the fifth member, NFAT5/TonEBP (tonicityresponsive enhancer-binding protein), by osmotic shock (214).”
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells (2015, neutral): “The transcription factor nuclear factor of activatedT cells (NFAT) is well establishedasakey regulatorofTcell activation (Crabtreeand Olson,2002;Hoganetal., 2003;Macian, 2005;Raoetal., 1997).”
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. (2007, background): “A549 cells have increased [Ca 2+ ] i (Figure 5A), a direct activator of calcineurin and thus NFAT (Macian, 2005).”
CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation (2017, background): “nuclear translocation and enhanced NFAT transcriptional activity (22,26).”
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. (2010, background): “This signal is likely derived from a dimerization partner, as it is well known that NFAT proteins dimerize with many other TFs (Macian 2005).”
Zinc as a Gatekeeper of Immune Function (2017, background): “After TCR triggering, it is dephosphorylated by CN, serine/threonine phosphatase [199].”
Ion Channels in Innate and Adaptive Immunity (2015, background): “An essential function of Ca2+ influx through CRAC channels is the regulation of cytokine and chemokine gene expression, primarily via the calcineurin-NFAT pathway (3, 166).”