Transcriptional mechanisms underlying lymphocyte tolerance.

By F. Macian, Francisco J. Garcia-Cozar, S. Im, H. Horton, M. Byrne, Anjana Rao. Cell, 2002

728 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aae585fb91f666e7f0f4f0b6b237830f612aeed6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Junying Yuan
2. D. Ofengeim

In Immunology

1. Laura M. McLane
2. Mohamed S. Abdel-Hakeem
3. Anjana Rao
4. P. Hogan
5. Angelika Schmidt
6. P. Krammer
7. E. Wherry
8. Li-Fan Lu

In Molecular Biology

1. P. Hogan
2. Anjana Rao
3. D. Speiser
4. P. Krammer
5. Petra Baumgaertner
6. Junying Yuan
7. D. Ofengeim

Citations in the corpus

• Transcriptional regulation by calcium, calcineurin, and NFAT. (2003, background): “We discuss the finding that NFAT and NFAT–Fos–Jun complexes activate distinct subsets of target genes in lymphocytes (Macián et al. 2002).”
• Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. (2011, methodology): “Nevertheless, we made an attempt by evaluating 29 anergy-related genes described in a model of ionomycin-induced anergy and a model of deletional tolerance (38, 39).”
• CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “NFAT is a family of transcription factors with well-established roles in T cell activation (261, 262), T cell anergy (263), and T cell exhaustion (7, 9, 122).”
• Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “…that Cbl-b deficient T cells are less sensitive to suppression by Tregs (Wohlfert et al., 2004), data on inhibitory NFAT complexes imply that Treg-suppressed Tcons display features of anergy, as both NFAT1 and Cbl-b are crucial in anergy induction (Macian et al., 2002; Soto-Nieves et al., 2009).”
• TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion (2019, background): “We show that the high-mobility group (HMG)-box transcription factors TOX and TOX2, as well as members of the NR4A family of nuclear receptors, are targets of the calcium/calcineurin-regulated transcription factor NFAT, even in the absence of its partner AP-1 (FOS-JUN).”