Regulation of transcription factors by neuronal activity

By A. West, Eric C. Griffith, Michael E. Greenberg. Nature Reviews Neuroscience, 2002

634 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c6ae79346548f4b09c43f75095b67b90f85d14f3

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Structural plasticity and memory (2004, background): “and subsequently, over several hours, by activation of gene transcription and protein synthesi”
MAPK cascade signalling and synaptic plasticity (2004, background): “CREB as a target for ERK during plasticity The transcription factor CREB (cyclic-AMP-responsive element ( CRE )-binding protein) is perhaps the most intensively studied kinase substrate in the field of learning and memory (recently reviewed in Ref”
NF-κB functions in synaptic signaling and behavior (2003, background): “Despite its well-characterized function in the immune system, large gaps remain in our understanding of the mechanisms and consequences of NF-κB activation in the central nervous system (CNS”
NF-κB/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity (2006, background): “As transcriptional regulators, NF- B/Rel proteins can potentially either positively or negatively regulate the expression of genes governing changes in synaptic plasticity and cognitive functions (73).”
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. (2006, background): “S421 affects the ability of MeCP2 to regulate neuronal activity-dependent gene expression, focusing on Bdnf promoter IV transcription, a well-characterized model for activity-dependent gene expression (West et al., 2002) and a putative target of MeCP2-mediated repression (Chen et al., 2003).”
Rapid synaptic scaling induced by changes in postsynaptic firing. (2008, background): “CaMKIV is a known transcriptional regulator (Soderling, 1999), and some forms of synaptic plasticity require gene expression for their induction or maintenance (West et al., 2002), but it is unknown whether synaptic scaling is transcription dependent.”