How neutrophils kill microbes.

By A. Segal. Annual Review of Immunology, 2005

1,824 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/df44e4344bf3f05ca3d114f9f5d2c5a00ae669b8

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Citations in the corpus

Reactive Oxygen Species and Neutrophil Function. (2016, background): “The evidence that these involve hydrogen peroxide or superoxide is not particularly strong, and their nature continues to be debated (15, 41, 50, 55, 75, 78).”
DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. (2006, neutral): “Conclusions Neutrophils effectively kill bacteria through a variety of mechanisms involving phagocytosis and/or degranulation, including proteolytic enzymes, antimicrobial peptides, and reactive oxygen and nitrogen species [8].”
Metabolic Regulation of Immune Responses (2014, background): “Upon pathogen sensing, the latent cytosolic NADPH oxidase complex (NOX) becomes activated in these cells, allowing for generation of the microbicidal H2O2 (13) (Figure 2).”
How human neutrophils kill and degrade microbes: an integrated view (2007, background): “As a consequence of the resultant high intraphagosomal [Kþ], granule proteases are released from their inactive state complexed with proteoglycans and made available for anti-microbial action (99).”
The hypersensitive response; the centenary is upon us but how much do we know? (2008, background): “Further, initiation of cell death in the lsd1 mutant was influenced by glutathione levels, if not by redox status (Senda and Ogawa, 2004).”
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, background): “Very rapidly, however, ROS production stops, phagosome acidification resumes, and the pH drops within 30 min of phagocytosis (Segal, 2005; Segal et al., 1981).”
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases (2010, neutral): “oxygen metabolites (Segal, 2005).”
Myeloperoxidase: a front‐line defender against phagocytosed microorganisms (2013, background): “also been proposed [3], although subsequently challenged [4,”
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps (2010, background): “Vol. 207 No. 9 1853-1862 www.jem.org/cgi/doi/10.1084/jem.20100239 1853 Br ief Definit ive Repor t Peripheral blood neutrophils are the first line of defense after bacterial infection (Segal, 2005; Nathan, 2006).”
Regulation of reactive oxygen species generation in cell signaling (2011, background): “The catalytic protein Nox2 serves as the core protein of NADPH oxidase complex in phagocytic cells (Segal, 2005).”
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood (2007, background): “During localized or less severe bacteremia, the platelet is not activated and neutrophils use the more classical Fc and complement receptors to grab and phagocytose bacteri”
Neutrophils in the activation and regulation of innate and adaptive immunity (2011, background): “A comprehensive overview of the functions of neutrophils in the innate immune system is beyond the scope of this section and the reader is referred to previous reviews for a backgroun”
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets (2011, background): “NOX2 oxidase-expressing leukocytes classically comprise cells of the innate immune system — that is, neutrophils, monocytes and macrophage”
Novel cell death program leads to neutrophil extracellular traps (2007, positive): “These data further support our fi nding that NADPH oxidase is essential not only for phagosomal killing (Fang, 2004; Segal, 2005) but also for NET formation.”