Myeloperoxidase: a front‐line defender against phagocytosed microorganisms

By S. Klebanoff, A. Kettle, H. Rosen, C. Winterbourn, W. Nauseef. Journal of Leukocyte Biology, 2013

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Reactive Oxygen Species and Neutrophil Function. (2016, background): “Although neutrophils from individuals with MPO deficiency kill many microorganisms poorly, in contrast to CGD, MPO deficiency is relatively common and only rarely associated with serious infection (56, 58).”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “Additionally, upon oxidative burst in PMNs the granule-localized enzyme myeloperoxidase (MPO) converts hydrogen peroxide into the highly bactericidal hypochlorous acid (HOCl) at neutral or low pH, which is believed to enhance clearance of pathogens (Figure 2) (Klebanoff, 1970; Rosen and Klebanoff, 1”
Pathogenicity and virulence of Staphylococcus aureus (2021, background): “HOCl is the major ROS effector molecule [115].”
Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Inherited MPO deficiency is frequent in humans, but MPO-deficient individuals are mostly asymptomatic, except for a small subset that suffers from diabetes [170].”