Regulation of reactive oxygen species generation in cell signaling

By Y. Bae, Hyunjin Oh, S. Rhee, Young Do Yoo. Molecules and Cells, 2011

621 citations recorded by the source corpus.

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5ca0a45c7f47277a2fa8184ce1e389a13eecd985

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In Immunology

1. Erin R Green
2. G. T. Nguyen
3. J. Mecsas
4. M. Duennwald
5. Vy Ngo

In Molecular Biology

1. Erin R Green
2. G. T. Nguyen
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In Physiology

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Citations in the corpus

• Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022, background): “At low to moderate levels, ROS plays an important role in normal cellular processes, serving as secondary messengers in intracellular signalling cascades that mediate cell growth, autophagy, inflammatory and immune function, and contribute to overall redox regulation [16,17].”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “Studies have shown that CYP2E1 induces higher ROS production than other CYP enzymes and that its activation or overexpression leads to increased ROS levels [152, 154].”
• Oxidative Stress in Aging Human Skin (2015, background): “A leaky transfer of electrons can result in the formation of oxygen radicals, especially superoxide [92,93].”
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “While various cell types can produce ROS by different machineries to regulate and influence cellular processes (Trachootham et al., 2008; Bae et al., 2011; Ray et al., 2012; Nathan and Cunningham-Bussel, 2013; Navarro-Yepes et al., 2014; Reczek and Chandel, 2014; Schieber and Chandel, 2014; Gorlach ”