DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps.

By J. Buchanan, A. J. Simpson, Ramy Karam Aziz, George Y. Liu, Sascha A. Kristian, Malak Kotb, J. Feramisco, V. Nizet. Current Biology, 2006

731 citations recorded by the source corpus.

Subfields: Immunology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/333f22295a27c30c75663cf185c8e0cb1a2d6138

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Arturo Zychlinsky
2. P. Kubes
3. V. Brinkmann
4. V. Papayannopoulos
5. K. Martinod
6. D. Wagner
7. B. Yipp
8. Guoyao Wu

In Public Health, Environmental and Occupational Health

1. V. Papayannopoulos
2. Arturo Zychlinsky
3. Kathleen D. Metzler

Citations in the corpus

• Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis (2011, background): “In humans, NETs have been visualized in physiologic host responses to infections (44, 50) and have been implicated in the pathology of anti-neutrophil cytoplasmic Ab-induced vasculitis (51).”
• Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood (2007, background): “Numerous studies have reported that activated neutrophils release structures made of DNA in vitro and in tissue”
• Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. (2012, background): “…roles of NETs in host defense, NETs have been observed within tissues such as the skin and lungs, where they contribute to the containment of acute bacterial infections in animal models of cellulitis, necrotizing faciitis, and pneumonia (Beiter et al., 2006; Buchanan et al., 2006; Li et al., 2010).”
• Neutrophil extracellular traps: Is immunity the second function of chromatin? (2012, background): “JCB • VOLUME 198 • NUMBER 5 • 2012 780 Pathogenic bacteria have evolved surface nucleases that detach them from the NETs to permit dissemination, as is the case with group A Streptococci (Buchanan et al., 2006) and pneumococci (Beiter et al.”
• Thrombosis: tangled up in NETs. (2014, background): “23,33,34 Venous injury There may be a difference between arterial and venous responses to injury with respect to NETs.”
• Amino acids and immune function (2007, background): “Recently, neutrophil extracellular traps, comprising DNA and proteins as major structural components, were discovered as a mechanism against bacterial infection (Buchanan et al. 2006).”
• Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010, background): “Notably, microbes have evolved virulence factors to degrade NETs (Beiter et al., 2006; Buchanan et al., 2006; Walker et al., 2007; Lauth et al., 2009).”
• PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps (2010, methodology): “NETs trap and kill pathogenic bacteria, such as Shigella flexneri (Brinkmann et al., 2004) and group A Streptococcus pyogenes (GAS; Buchanan et al., 2006).”
• Beneficial suicide: why neutrophils die to make NETs (2007, neutral): “gov/sites/entrez?db=genomeprj&cmd=Retrieve&dopt=Overview&list_uids=12327">group A Streptococcus”