How human neutrophils kill and degrade microbes: an integrated view

By W. Nauseef. Immunological Reviews, 2007

748 citations recorded by the source corpus.

Subfields: Immunology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/b8cb71182fb51c417164ba85add8cefc78b49e96

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Arturo Zychlinsky
2. N. Borregaard
3. C. Winterbourn
4. V. Papayannopoulos
5. Kathleen D. Metzler
6. M. Hampton
7. A. Kettle
8. W. Nauseef

In Public Health, Environmental and Occupational Health

1. C. Winterbourn
2. N. Borregaard
3. Arturo Zychlinsky
4. V. Papayannopoulos
5. A. Kettle
6. A. Ridley
7. S. Heasman
8. Kathleen D. Metzler

Citations in the corpus

• International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, background): “For instance, neutrophil myeloperoxidase released from the azurophil granules helps to convert hydrogen peroxide to hypochlorous acid (Nauseef, 2007), a metabolite of importance both for killing invading microbes and for the resolution of inflammation.”
• Myeloperoxidase: a front‐line defender against phagocytosed microorganisms (2013, background): “Rapid and sustained antimicrobial action in neutrophils depends on synergistic cooperation among the many toxic agents generated in and delivered to the phagosome [26, 48].”
• Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “Most studied is NOX2 in phagocytic cells, which is a critical component of their defense against invading pathogen”
• Neutrophils, from marrow to microbes. (2010, background): “Activation of neutrophil respiratory burst and mechanisms of microbial killing have been reviewed recently (El-Benna et al., 2009; Robinson, 2008, 2009; Holland, 2010; Nauseef, 2007; Flannagan et al., 2009).”
• A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis (2014, neutral): “Patients with chronic granulomatous disease (CGD), who are deficient in NADPH oxidase activity, and individuals who are completely deficient in myeloperoxidase ( D MPO; Figure S1A) are susceptible to opportunistic infections, particularly to fungal pathogens (Nauseef, 2007).”
• Oxidative stress and antioxidative responses in plant-virus interactions (2016, neutral): “elimination of engulfed pathogenic microorganisms [110,114,133].”
• Rapid Neutrophil Destruction following Phagocytosis of Staphylococcus aureus (2010, background): “Human polymorphonuclear leukocytes (PMNs or neutrophils) are critical for host defense against invading bacteria. The acute inflammatory response to infection is characterized by the rapid recruitment of neutrophils. After ingestion of microorganisms, PMNs generate intraphagosomal reactive oxygen sp”
• Reactive Oxygen Species and Neutrophil Function. (2016, background): “This killing occurs within phagosomes, and it involves a battery of oxidative and nonoxidative antimicrobial mechanisms (50, 55, 56).”
• Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010, background): “MPO catalyzes the oxidation of halides by hydrogen peroxide (Hazen et al., 1996; Eiserich et al., 1998; Nauseef, 2007).”
• Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “The NADPH oxidase reduces oxygen to superoxide, which then contributes to bacterial killin”