NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.

By A. Savina, C. Jancic, S. Hugues, P. Guermonprez, Pablo Vargas, I. Moura, A. Lennon-Duménil, Miguel C. Seabra, G. Raposo, S. Amigorena. Cell, 2006

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Subfields: Immunology

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Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo (2007, background): “; however, some antigens can be remarkably long-live”
NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, positive): “A recent study has demonstrated that the NADPH oxidase NOX2 is recruited to the early phagosomes of dendritic cells, which produces alkalinization of the phagosomal lumen by generating low levels of ROS (251).”
Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition (2016, positive): “…able to transport intact antigens to the TdLN are consistent with the low expression levels of lysosomal degradative enzymes (Miller et al., 2012; Savina et al., 2006) and in line with our previous results showing that lung-resident CD103+ DCs are uniquely able to transport intact viral antigens…”
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting (2007, background): “This limits the hydrolytic capacity of the phagosome, which seems to be crucial for efficient cross-presentatio”