The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

By Cheng-Jun Hu, Aneesa Sataur, Liyi Wang, Hongqing Chen, M. C. Simon. 2007

325 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d9eec3ea3314f4977496ee2b2b1c9926286c41f0

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In Cancer Research

1. G. Semenza
2. P. Ratcliffe
3. W. Kaelin
4. N. Prabhakar
5. J. Espinosa
6. V. L. Dengler
7. M. Galbraith
8. Navdeep S. Chandel

In Molecular Biology

1. G. Semenza
2. P. Ratcliffe
3. W. Kaelin
4. J. Espinosa
5. V. L. Dengler
6. M. Galbraith
7. N. Prabhakar
8. C. V. Dang

In Oncology

1. J. Espinosa
2. V. L. Dengler
3. W. Kaelin
4. M. Galbraith
5. G. Semenza
6. P. Vaupel

Citations in the corpus

• Hypoxia-Inducible Factor 1 (HIF-1) Pathway (2007, background): “Functional specificity for transactivation by HIF-1α and HIF-2α appears to reside in amino acid residues 415 to 659 and 418 to 619, respectively (21).”
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008, background): “Transcriptional selectivity is not mediated by selective DNA binding at HREs but involves sequences lying C terminal to DNA binding and dimerization domains (Hu et al., 2007; Lau et al., 2007).”
• Transcriptional Regulation by Hypoxia Inducible Factors (2013, background): “Instead, the N-TADs appear to contribute to target gene selectivity (Hu et al., 2007; Lau et al., 2007).”
• ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “Interaction of HIF-2 with the ETS family transcription factor ELK-1 may be required for HIF-2-dependent transactivation of some target genes in some cell types (2, 122).”