The role of oxygen availability in embryonic development and stem cell function

By M. C. Simon, B. Keith. Nature reviews. Molecular cell biology, 2008

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Mitochondrial Glutathione, a Key Survival Antioxidant (2009, background): “Hypoxia occurs in tissues when the availability of O2 is insufficient for the cellular demand, as happens in physiologic (embryonic development, exercising muscle) and pathologic conditions (stroke, tissue ischemia, inflammation, solid-tumor formation) (6, 116, 126, 132, 143).”
The impact of O2 availability on human cancer (2008, background): “Of the three HIFα proteins, HIF1α and HIF2α (also known as endothelial PAS domain protein 1 ( EPAS1 )) have been the most extensively characterize”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “The effects of hypoxia on development have been the subject of many reviews, but its direct effect on stem cell biology has received little attention (Simon and Keith, 2008).”
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (2009, background): “These hypoxic niches may have a role in limiting differentiation and maintaining stemnes”
Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “Cells respond to low O 2 availability by stimulating several hypoxia-inducible factors (HIFs) and other molecules, including mTOR, endoplasmic reticulum (ER)-associated kinases and soluble guanylate cyclases that mediate O 2 homeostasis and are responsible for the development of the vasculature, p”