Transcriptional Regulation by Hypoxia Inducible Factors

By V. L. Dengler, M. Galbraith, J. Espinosa. Critical reviews in biochemistry and molecular biology, 2013

726 citations recorded by the source corpus.

Abstract The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b107c14c6df20591667d81d9aa2cce5cab9565e0

Citations in the corpus

• Vitamin C physiology: the known and the unknown and Goldilocks (2016, neutral): “In the nucleus, HIF-1α forms dimers with HIF-1 β, and the dimer binds to DNA to transcribe target genes (Dengler et al., 2014).”