Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1

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Targeting lactate metabolism for cancer therapeutics. (2013, neutral): “21 , 22).”
MYC on the Path to Cancer (2012, background): “…between Myc and ribosome biogenesis has been documented in specific cell types (Challagundla et al., 2011; Chan et al., 2011; Greasley et al., 2000; Kim et al., 2000; Schlosser et al., 2005; Schlosser et al., 2003) and in Myc-driven tumorigenesis in vivo (Barna et al., 2008; Stumpf and Ruggero,…”
Otto Warburg's contributions to current concepts of cancer metabolism (2011, background): “; as such, the genomic and metabolic networks of cancer cells are disrupted not only by cell-autonomous genetic mutations but also by hypoxi”
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008, background): “Cooperative interactions between classical HIF (HRE) and Myc (E box) binding sites have been defined at some promoters (Kim et al., 2007).”
Hypoxia, HIF1 and glucose metabolism in the solid tumour (2008, background): “However, MYC and HIF have been reported to cooperate in driving gene expressio”