The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

By Stephan D. Frank, B. Gaume, E. Bergmann-Leitner, W. Leitner, E. Robert, Frédéric Catez, Carolyn L. Smith, R. Youle. Developmental Cell, 2001

1,761 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d6c9ef4c66d3871a5d338fd5ca65810bb5d50269

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Citations in the corpus

The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (2008, background): “Mutations in Drp1 and Fis1 siRNA were previously shown to inhibit apoptosis by preventing cytochrome c release from mitochondria (Frank et al., 2001; James et al., 2003; Lee et al., 2004).”
Mitochondria in health and disease: perspectives on a new mitochondrial biology. (2004, result): “This is consistent with previous reports from the same lab who showed that suppression of Drp1, the protein involved in mitochondrial fission, inhibited the progression to apoptosis (Frank et al., 2001).”
Mitochondria: In Sickness and in Health (2012, background): “Although DRP1’s positive role in apoptosis is independent of its role in the regulation of mitochondrial structure per se, mitochondrial shape is likely to be an important factor in MOMP (Cassidy-Stone et al., 2008; Montessuit et al., 2010).”
Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury (2010, neutral): “experiments (5) (in mM: KH2PO4 1, NaHCO3 10, MgCl2.”
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis (2002, methodology): “Cells were probed with mouse anti-Bax (6A7) mAb (Hsu and Youle, 1998), affinity-purified anti–human Mfn2 antibodies, affinity-purified anti–human Drp1 polyclonal antibodies (Frank et al., 2001).”
Apoptosis: controlled demolition at the cellular level (2008, background): “Although more subtle, the Golgi, endoplasmic reticulum (ER) and mitochondrial networks also undergo pronounced fragmentation during apoptosis, and numerous proteins are released from the mitochondrial intermembrane spac”
The role of mitochondria in apoptosis. (2008, background): “(92) and also by down regulation of Drp1 using RNAi (97).”
Functions and dysfunctions of mitochondrial dynamics (2007, background): “Inhibition of fission activity blocks mitochondrial fragmentation, reduces cytochrome c release and can reduce or delay cell death depending on the experimental syste”
Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity (2004, background): “In mammalian cells, the induction of apoptosis activates mitochondrial division to form fragmented mitochondria, which is apparently related to the progression of apoptosis (Frank et al., 2001).”
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development (2003, background): “Second, time-lapse fluorescence microscopy of cultured HeLa cells shows that the mitochondria are organized into extensive tubular networks that undergo frequent fusion and fission (Rizzuto et al., 1998).”