Mitochondria in health and disease: perspectives on a new mitochondrial biology.

By M. Duchen. Molecular Aspects of Medicine, 2004

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How researchers see this paper

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Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Mitochondrial calcium overload also impedes mitochondrial respiration and results in ATP depletion disabling Na + /K + ATPase and increasing intracellular Na + (119, (122) (123) (124) .”
Mitochondria and neuronal activity. (2007, background): “Data from these studies have been summarized and discussed in a variety of excellent general reviews on mitochondrial genetics, biochemistry, physiology, and pathology, characterizing mitochondria as a highly dynamic, sensitive, but potentially harmful entity (15, 24, 55, 80, 145, 179).”
Mitochondrial dysfunction and molecular pathways of disease. (2007, background): “Mechanisms of mitochondria-induced injury Damage to mitochondria is caused primarily by reactive oxygen species (ROS) generated by the mitochondria themselves (Wei et al., 1998; Duchen, 2004).”
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide. (2011, background): “Several extensive and excellent reviews explore these mitochondrial bioenergetics in more detail (7,14,15).”