Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

By S. Ong, S. Subrayan, Shiang Y. Lim, D. Yellon, S. Davidson, D. Hausenloy. Circulation, 2010

946 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/633874ddcb59326a7ecf91f1ead5f5a19bfa07c9

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Citations in the corpus

The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Knockdown of Drp1 (79) prevents ischemia/reperfusioninduced mitochondrial fragmentation and is associated with reduced cell death in HL-1 cells following ischemia/reperfusion insult.”
Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control (2012, background): “Inhibition of mitochondrial fission attenuates disease progression in models of neurodegenerative and cardiovascular diseases.(130,137,138) Studies have found that excessive DRP1-mediated mitochondrial fission contributes to apoptotic cell death.”
Mitochondria: In Sickness and in Health (2012, background): “…and drug toxicities are also associatedwith increasedmitochondrial fragmentation in cultured cells models and in animal models of myocardial infarction and drug induced renal toxicity, inhibition of mitochondrial division has shown therapeutic promise (Brooks et al., 2009; Ong et al., 2010).”
Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “Ischemia cause mitochondrial fragmentation, which mainly depends on Drp1 and links to increased release of ROS and calcium overload.(10,11) High level of ROS can induce mitochondrial fission during acute IRI, while pre-treatment with scavengers of mitochondrial ROS-SkQ1 or Trolox, reduces the phosph”
Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2011, background): “For example, mitochondrial fission occurs in the kidneys and heart after acute ischemia/reperfusion injury in mice, and prevention of this process is beneficial (5, 32).”
Autophagy and Mitophagy in Cardiovascular Disease. (2017, background): “The relatively nonspecific inhibitor of mitophagy mdivi-1 (which interferes with mitochondrial fission) also limited myocardial infarct size in mice subject to coronary artery occlusion and reperfusion.(77) Along similar lines, Bnip3 mice exhibited reduced myocardial damage and preserved cardiac per”
Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “362,363 Recently, in vitro experimentation showed that Mdivi-1 partially ameliorated the aberrations in mitochondrial dynamics within human aortic smooth muscle cells (HAoSMCs) derived from bicuspid aortic valve (BAV) patients.”
Cell Biology of Ischemia/Reperfusion Injury (2012, background): “Indeed, inhibition of mitochondrial fission has been shown to reduce I/R-induced mitochondrial fragmentation and exerts cardioprotective effects in I/R by preventing MPT pore opening (Ong et al., 2010).”